Nutrition for Sustainable Weight Loss: A UK Clinical Pillar Guide
A practical, evidence-led nutrition guide focused on satiety, protein, fibre, and long-term habits - especially for people using Wegovy or Mounjaro.
Nutrition is the foundation of sustainable weight loss, but it does not need to be extreme to be effective. Long-term results are built on patterns that support appetite control, nutrition adequacy, and consistency - not short-term restriction or rigid rules.
This pillar explains the key nutritional principles that support weight loss, metabolic health, and long-term maintenance, particularly for people using weight loss medications such as Wegovy (semaglutide) or Mounjaro (tirzepatide).
Nutrition and appetite regulation
Appetite is influenced by hormones, blood sugar regulation, sleep, stress, and the composition of meals. Diets that are very low in protein, fibre, or overall energy can increase hunger and make weight regain more likely.
The key foundations: protein, fibre, and volume
Protein helps you feel fuller for longer and plays a crucial role in maintaining muscle mass during weight loss, particularly when appetite is reduced by medication. Fibre supports gut health, improves fullness, and slows digestion. High-volume, minimally processed foods help maintain satisfaction with fewer calories.
Nutrition while using Wegovy or Mounjaro
GLP-1 medications can significantly reduce appetite. Helpful strategies include prioritising protein, choosing smaller meals if nausea occurs, avoiding very fatty meals early in treatment, and maintaining hydration.
Meal structure over meal rules
Rather than rigid food rules, a repeatable meal structure works best. Most meals benefit from a protein source, vegetables or fruit, and carbohydrates where appropriate. A medical approach avoids labelling foods as “good” or “bad”.
Weight loss, nutrition, and maintenance
Adequate nutrition supports muscle preservation, metabolic health, and weight maintenance - especially if medication is reduced or stopped.
How to use this pillar
Use this hub to explore protein targets, meal planning, nutrition while on medication, managing cravings, eating out, and long-term maintenance.
Further reading
• NHS Eatwell Guide
• British Dietetic Association resources
• NICE guidance on weight management