Evidence-led articles exploring weight loss medications, including GLP-1 treatments like Wegovy and Mounjaro, how they work, and what to consider when they're prescribed responsibly.
Back to Health HubWhat the published trials and Phase 3 toplines have reported about retatrutide's side-effect profile: the GI effects, the dose-dependent heart-rate observation, and what is still being investigated.
The Phase 2 NEJM trial of retatrutide reported up to 24.2% mean weight reduction at 48 weeks. What the trial measured, what it found, and what its limitations are — referenced to the published paper.
Orforglipron (Foundayo) was FDA-approved in April 2026. Here's the UK MHRA and NICE outlook, expected private and NHS access timelines, and likely UK pricing.
Orforglipron Phase 3 trials show ~11% weight loss in ATTAIN-1 and strong A1C drops in ACHIEVE-1. Here's what the data says and how it stacks up vs Wegovy and Mounjaro.
Orforglipron is Eli Lilly's investigational once-daily oral GLP-1 pill for weight loss and type 2 diabetes. How it works, and how it stacks up against Wegovy and Mounjaro.
Retatrutide is an investigational triple hormone receptor agonist from Eli Lilly, not approved in the UK. A clinical overview of what it is and how it differs from MHRA-approved options.
Retatrutide is the first investigational triple hormone receptor agonist to reach Phase 3 trials in obesity. This article explains in plain English how GLP-1, GIP and glucagon receptor activation work together, and why the combination matters.
Are weight loss medications safe.
Wegovy and Mounjaro are leading weight loss medications. Learn how they compare in effectiveness, side effects, and suitability in the UK.
Prescription Weight-Loss Medications vs Supplements: What’s the Difference?
Weight loss is not just about willpower. This article explains the biology of obesity and why medications like Wegovy and Mounjaro support long term weight management.
Mounjaro is a newer weight loss medication with a dual hormone approach. Learn how it works, how it compares to Wegovy, and what to expect in the UK.
Not everyone is suitable for weight loss medication. Learn who may benefit from treatments like Wegovy and Mounjaro, and how eligibility is assessed in the UK.
GLP-1 medications such as Wegovy and Mounjaro support weight loss by regulating appetite and fullness. Learn how they work, what to expect, and how they fit into treatment.
A balanced, UK-focused overview of prescription weight loss medications—how they work, who they’re for, expected results, side effects, and how to access treatment safely.
Wondering how quickly weight loss medications work? Learn when to expect appetite changes, weight loss results, and what influences progress.
Wegovy can cause side effects, especially when starting treatment. Learn what is common, what is less common, and how to manage symptoms safely in the UK.
Thinking about starting Wegovy for weight loss? Learn how it works, what to expect, potential side effects, and how to access treatment safely in the UK.
Mounjaro can cause side effects, particularly when starting treatment. Learn what is common, what is less common, and how to manage symptoms safely.
Weight loss medications support the body’s natural appetite and hormone systems. Learn how treatments like Wegovy and Mounjaro work, their benefits, limitations, and what to expect.